Quetiapine overdose. 1 View quetiapine information, including dose, uses, side-effects, pregnancy, breast feeding, monitoring requirements, important safety information and drug action. 2 Continue close medical supervision and monitoring until the patient fully recovers, which may take 2-3 days for cardiovascular effects (tachycardia, QTc prolongation) even in uncomplicated cases. 1, 2 Any sign or symptom of overdose requires immediate medical attention and quetiapine should be immediately withdrawn. Sep 12, 2024 · Discussions of the clinical use of these drugs, details concerning potential side effects, and general management of drug overdose are found elsewhere. Nov 3, 2020 · Quetiapine antagonises the mesolimbic dopamine (D2), serotonin, histamine the muscarninic M1 and peripheral alpha 1 receptors. Wilson H, Ridley S. Strachan PM, Benoff BA. 2006;26 (4):578-582. 8,9 Unfortunately, there is currently no available antidote to reverse quetiapine toxicity. Quetiapine Poisoning See also: Poisoning – Guidelines for initial management Resuscitation Key Points Recreational drugs are common co-ingestants If ionotropes are required, use noradrenaline as adrenaline paradoxically worsens hypotension All intentional self-poisonings in adolescents require screening for paracetamol ingestion and admission Compared to other antipsychotics quetiapine has been reported to be relatively safer in overdose. However, many people wonder, can you overdose on Seroquel? The short answer is yes. (See "General approach to drug poisoning in adults". How much Seroquel you need to take to overdose is different Here, we present the first case report of an intoxication with an extreme overdose of quetiapine (36 g), ingested by a 32-year-old female (62 kg bodyweight) to attempt suicide. . Mental status change, myoclonus, electrocardiographic changes, and acute respiratory distress syndrome induced by quetiapine overdose. Adverse side effects of Seroquel toxicity include kidney failure, hyperglycemia, diabetic coma, and death. Learn about its dosage, side effects, and more. Understanding the risks, symptoms, and treatment options can help prevent serious consequences. Quick action can save a life. When this happens, the user’s body is unable to handle the high levels of the drug that enters the system, eventually leading to the typical overdose symptoms. 2007;99 (2):301 Seroquel Overdose: Causes, Symptoms and Treatments Seroquel is an atypical antipsychotic drug. Feb 19, 2020 · Combining quetiapine with other medications or substances, especially those that depress the central nervous system, can significantly increase the Seroquel overdose risk. In large overdoses, patients may require intubation and ventilation for associated respiratory depression. Jul 8, 2024 · Official answer: Yes, it is possible to overdose on Seroquel (quetiapine). Aug 22, 2025 · Seroquel is an atypical antipsychotic medication that can be lethal in very high doses, or when mixed with other drugs. It is given for the treatment of mental disorders, primarily for the treatment of schizophrenia, bipolar disorder, and major depressive disorder. Mar 13, 2025 · Seroquel (quetiapine) is a prescription medication used to treat psychiatric conditions such as schizophrenia, bipolar disorder, and major depressive disorder. Antipsychotic drugs and the acute respiratory distress syndrome. A structured literature review and analysis were conducted to assess the relationship between the kinetic and Jan 1, 2026 · Seroquel (quetiapine) is a prescription medication commonly used to treat conditions such as bipolar disorder, schizophrenia, and major depressive disorder. We report a case with paranoid schizophrenia who attempted suicide with 1400 mg of quetiapine and manifested drowsiness, supraventricular tachycardia Dec 1, 2002 · Quetiapine overdose, alone or in combination with other medications, has resulted in QT prolongation (1), loss of consciousness (2), sinus tachycardia (3), and hypokalemia with first-degree heart block (4). Pharmacotherapy. A Seroquel overdose can affect breathing, heart rhythm, blood pressure, and consciousness, and symptoms may worsen faster than families expect. Br J Anaesth. This causes an anticholinergic effect (muscarinic receptors) in overdose and drowsiness (histamine receptor blockade). ) Nov 9, 2025 · All quetiapine overdose patients requiring hospitalization must be admitted to an intensive care unit. PubMed Google Scholar Crossref 16. In overdose, though, Seroquel can be fatal, and its cure Quetiapine overdose causes central nervous system depression and sinus tachycardia. Although a prolonged QTc occurs, its clinical significance is unclear because it is most likely caused by an … Quetiapine Overdose of quetiapine leads to tachycardia, CNS depression and hypotension Seroquel overdose is very much possible whether you take the medication alone or in combination with other drugs. Jul 31, 2023 · Seroquel is a prescription tablet used to treat bipolar I disorder and certain other mental health conditions. When taken appropriately, it preserves the chemicals within the brain to smooth the symptoms. Over the past decade, quetiapine has become one of the most commonly used psychotropic drugs in acute intoxication events worldwide. vzkjeazxdhnpysohxsgwjpbqbulcbnqlkfnuvqbdbkcck